Fast and Easy Detection of FV-Leiden
Lamp Human FV LEIDEN mutation kit (rs6025)

Risk Factors of Genetic Thrombosis: 

An in vitro diagnostic test that allows the detection and genotyping of a single point mutation (G1691A) of the human Factor V gene, referred to as Factor V Leiden mutation, directly from human whole blood.

graph FVL

FV-Leiden

Factor V Leiden thrombophilia is an inherited disorder of blood clotting. Factor V Leiden is the name of a specific mutation (genetic alteration) that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels. People who have the factor V Leiden mutation are at somewhat higher than average risk for a type of clot that forms in large veins in the legs (deep venous thrombosis, or DVT) or a clot that travels through the bloodstream and lodges in the lungs (pulmonary embolism, or PE).

Factor V Leiden is the most common inherited form of thrombophilia. Between 3 and 8 percent of the Caucasian (white) U.S. and European populations carry one copy of the factor V Leiden mutation, and about 1 in 5,000 people have two copies of the mutation. The mutation is less common in other populations.A mutation in the factor V gene (F5) increases the risk of developing factor V Leiden thrombophilia. The protein made by F5 called factor V plays a critical role in the formation of blood clots in response to injury. The Factor V protein is involved in a series of chemical reactions that hold blood clots together. A molecule called activated protein C (APC) prevents blood clots from growing too large by inactivating factor V. In people with the factor V Leiden mutation, APC is unable to inactivate factor V normally. As a result, the clotting process continues longer than usual, increasing the chance of developing abnormal blood clots.*1

*1Information courtesy of: Genetics Home Reference

Test procedure

 

  RAPIDITY: 1 minute hand-time & 30 minutes amplification + detection 

  SIMPLICITY: No laborious DNA extraction procedure 

  EFFICIENCY: Perfect distinction of the heterozygote

FVL Ordering Info