LAMP Human HLA-B27 detection KIT
The LAMP Human HLA-B27 KIT is an in vitro diagnostic test intended for the qualitative detection of a tag SNP (rs4349859) for HLAB27 alleles by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA. This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
Regulatory Status: CE-IVD
Format: 24 / 96 reactions
Target gene: HLA-B27
Linked disease: Ankylosing spondylitis (AS)
Genetic marker: rs4349859 (G>A)
Method: LAMP + meting curve analysis
Sample: EDTA whole blood - no DNA extraction required - or extracted DNA
Compatible instruments: LightCycler 480 I&II / Cobas z 480 (Roche); CFX96 / CFX Opus 96 (Bio-Rad); QuantStudio 1/3/5 & 6/7 Flex (Applied Biosystems); MIC qPCR (Bio Molecular Systems); LC-Genie III & Genie HT (Optigene)
Software / result interpretation: Automated genotype calling via GeneFox software; mandatory visual confirmation of the melting curve
Turn around time: < 1h
General information
Advantages
Linked products
Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis and affects approximatively 0.5% of the population.
Accumulating evidence has demonstrated that human leukocyte antigen (HLA) class I molecule B27 (HLA-B27) is strongly associated to AS: more than 90 % of AS patients are HLA-B27 positive.
Background information
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