LAMP Human DPD Defiency KIT - DPYD*7
The LAMP Human DPD deficiency KIT is an in vitro diagnostic test intended for the qualitative detection of the less functional DPYD allele *7 by Loop-mediated isothermal amplification (LAMP).
This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
Regulatory Status: RUO
Format: 24 reactions
Target gene: DPYD
Drug relevance: Fluoropyrimidines, including drugs like 5-fluorouracil (5-FU), capecitabine, and tegafur
Variants detected: DPYD*7 (rs72549309, 295-298delTCAT)
Method: LAMP + meting curve analysis
Sample: EDTA whole blood - no DNA extraction required - or extracted DNA
Compatible instruments: LightCycler 480 I&II / Cobas z 480 (Roche); CFX96 / CFX Opus 96 (Bio-Rad); QuantStudio 1/3/5 & 6/7 Flex (Applied Biosystems); MIC qPCR (Bio Molecular Systems); LC-Genie III & Genie HT (Optigene)
Turn around time: < 1h
General information
Advantages
Linked products
DPYD*7 also indicated as rs72549309, 295-298delTCAT, this variant refers to a frameshift mutation that leads to a non-functional form of the DPD enzyme.
Carrier frequency in the European population: 0.01%
Background information
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