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The LAMP Human DPD4var KIT is an in vitro diagnostic test intended for the qualitative detection of four different non-functional or less functional DPYD alleles (*2A, *13, c.2846A>T, c.1129-5923C>G) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA. This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.

Four decreased function DPYD variants are associated with DPD deficiency. They are of primary relevance due to their population frequency and established impact on enzyme function and toxicity risk: 

  • c.190511G>A (rs3918290, also known as DPYD*2A), 
  • c.1679T>G (rs55886062, DPYD *13)
  • c.2846A>T (rs67376798, p.D949V)
  • HapB3. 

Among these variants, c.190511G>A and c.1679T>G have the most significant effect on DPD activity, while c.2846A>T and HapB3 lead to a moderate reduction in DPD activity [1].

[1]https://files.cpicpgx.org/data/guideline/publication/fluoropyrimidines/2017/29152729.pdf

Test principle

Advantages

icon fast
Fast
icon No-DNA-extraction
No DNA extraction
icon comprehensive
Compatible with a variety of qPCR machines
icon easy-to-use
Automatic interpretation of the results

Linked products

LaCar
The LAMP Human DPD deficiency KIT is an in vitro diagnostic test intended for the qualitative detection of four different non-functional or less functional DPYD alleles by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA.
LaCar
The LAMP Human DPD4var KIT is an in vitro diagnostic test intended for the qualitative detection of four different non-functional or less functional DPYD alleles by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA.
LaCar
The LAMP Human DPDrs11 KIT is an in vitro diagnostic test intended for the qualitative detection of the less functional DPYD allele c.557A>G (rs115232898) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA.

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