LAMP Human DPD Defiency KIT - DPYD rs115232898
The LAMP Human DPDrs11 KIT is an in vitro diagnostic test intended for the qualitative detection of the less functional DPYD allele c.557A>G (rs115232898) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA. This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
Regulatory Status: RUO
Format: 24 reactions
Target gene: DPYD
Drug relevance: Fluoropyrimidines, including drugs like 5-fluorouracil (5-FU), capecitabine, and tegafur
Variants detected: DPYD (rs115232898)
Method: LAMP + meting curve analysis
Sample: EDTA whole blood - no DNA extraction required - or extracted DNA
Compatible instruments: LightCycler 480 I&II / Cobas z 480 (Roche); CFX96 / CFX Opus 96 (Bio-Rad); QuantStudio 1/3/5 & 6/7 Flex (Applied Biosystems); MIC qPCR (Bio Molecular Systems); LC-Genie III & Genie HT (Optigene)
Turn around time: < 1h
General information
Advantages
Linked products
In addition to the four variants of primary relevance, some guidelines suggest the detection of c.557A>G (rs115232898, p.Y186C), as this decreased function variant is relatively common in individuals with African ancestry (3-5% carrier frequency).
Background information
You have a question regarding our products ? You want to know more about our method ?
Find out about our other expertises
