LAMP Human DPD Defiency KIT - DPYD*9A
The LAMP Human DPD9 KIT is an in vitro diagnostic test intended for the qualitative detection of the less functional DPYD allele *9A (c.85T>C) by Loop-mediated isothermal amplification (LAMP).
This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
Regulatory Status: RUO
Format: 24 reactions
Target gene: DPYD
Drug relevance: Fluoropyrimidines, including drugs like 5-fluorouracil (5-FU), capecitabine, and tegafur
Variants detected: DPYD*9A (rs1801265, c.85T>C)
Method: LAMP + meting curve analysis
Sample: EDTA whole blood - no DNA extraction required - or extracted DNA
Compatible instruments: LightCycler 480 I&II / Cobas z 480 (Roche); CFX96 / CFX Opus 96 (Bio-Rad); QuantStudio 1/3/5 & 6/7 Flex (Applied Biosystems); MIC qPCR (Bio Molecular Systems); LC-Genie III & Genie HT (Optigene)
Turn around time: < 1h
General information
Advantages
Linked products
DPYD*9A also indicated as (rs1801265, c.85T>C), this variant refers to a missense mutation that leads to a mutant form of the DPD enzyme.
Carrier frequency in the European population 17-20%; in African American populations: 13-39%; in Asian populations: 3-5%.
Background information
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