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DPD Deficiency

Dihydropyrimidine dehydrogenase (DPD) is an essential enzyme for the metabolism of fluorouracil and capecitabine, two common chemotherapy drugs. Genetic mutations on the DPYD gene are known to decrease the activity of the enzyme. Individuals who carry at least one copy of no-functional DPYD variants, may not be able to metabolize those drugs at normal rates, and are at risk of potentially life-threatening toxicity. For this reason, the European Medicines Agency (EMA) and other working groups highly recommend the DPD testing prior to treatment with fluorouracil, capecitabine, tegafur, and flucytosine [1].

[1] https://www.ema.europa.eu/en/news/ema-recommendations-dpd-testing-prior-treatment-fluorouracil-capecitabine-tegafur-and-flucytosine

LaCar
The LAMP Human DPD deficiency KIT is an in vitro diagnostic test intended for the qualitative detection of four different non-functional or less functional DPYD alleles by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA.
LaCar
The LAMP Human DPD4var KIT is an in vitro diagnostic test intended for the qualitative detection of four different non-functional or less functional DPYD alleles by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA.
LaCar
The LAMP Human DPD4var KIT is an in vitro diagnostic test intended for the qualitative detection of four different non-functional or less functional DPYD alleles by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA.
LaCar
The LAMP Human DPD6 KIT is an in vitro diagnostic test intended for the qualitative detection of the less functional DPYD allele *6 by Loop-mediated isothermal amplification (LAMP).
LaCar
The LAMP Human DPD deficiency KIT is an in vitro diagnostic test intended for the qualitative detection of the less functional DPYD allele *7 by Loop-mediated isothermal amplification (LAMP). This assay is dedicated to professional use in diagnostic laboratories.
LaCar
The LAMP Human DPD9 KIT is an in vitro diagnostic test intended for the qualitative detection of the less functional DPYD allele *9A (c.85T>C) by Loop-mediated isothermal amplification (LAMP).
LaCar
The LAMP Human DPDrs11 KIT is an in vitro diagnostic test intended for the qualitative detection of the less functional DPYD allele c.557A>G (rs115232898) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA.

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